Antihistamines and Other Prognostic Factors for Adverse Outcome in Hyperemesis Gravidarum: A Follow-Up Study

Hyperemesis gravidarum (HG) may be defined as persistent, unexplained nausea and vomiting resulting in more than 5% weight loss, abnormal fluid and nutritional intake, electrolyte imbalance, dehydration, and ketonuria [1]. Symptoms often extend beyond the first trimester and can last throughout the entire pregnancy in as many as one-third of cases, leading to extreme weight loss and possibly a state of malnutrition and extended dehydration of pregnancy [2]. The purpose of this letter is to report on whether the findings in our publication in EJOG “Antihistamines and other Prognostic Factors for Adverse Outcome in Hyperemesis Gravidarum [3]” are reproducible in a new population sample.